cis-1,4-diaminocyclohexane-Pt(II) and -(IV) adducts with DNA bases and nucleosides

被引：9

作者：

Ali, MS ^{[1
]}

Khokhar, AR ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2003年 / 96卷 / 04期

关键词：

synthesis; platinum; cis-1,4-diaminocyclohexane; adducts;

D O I：

10.1016/S0162-0134(03)00262-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of new platinum(II) and platinum(IV) adducts of type [P-11(cis-1,4-DACH)LCI]NO3, where cis- 1,4-DACH=cis-1,4-diaminocyclohexane, and L=9-ethylguanine, 1-methylcytosine, adenine, adenosine, cytosine, cytidine, guanine, and [Pt-IV(cis-1,4-DACH)-Ltrans-(X)(2)Cl]NO3, (where Y=hydroxo or acetato), were synthesized and characterized by elemental analysis, infrared spectroscopy, and H-1 and Pt-195 nuclear magnetic resonance spectroscopy. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：452 / 456

页数：5

共 27 条

[1] Synthesis and characterization of platinum(II) and (IV) complexes containing hexamethyleneimine ligand:: crystal structure of [PtII(hexamethyleneimine)2(cyclobutanedicarboxylato)]•H2O [J].

Ali, MS ;

Thurston, JH ;

Whitmire, KH ;

Khokhar, AR .

POLYHEDRON, 2002, 21 (27-28) :2659-2665

[2] Preparation, characterization, and antitumor activity of new cisplatin analogs with homopiperazines:: crystal structure of [PtII(1-methylhomopiperazine) (methylmalonato)]•2H2O [J].

Ali, MS ;

Whitmire, KH ;

Toyomasu, T ;

Siddik, ZH ;

Khokhar, AR .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1999, 77 (3-4) :231-238

[3]

ALIKHAN SR, 2000, J COORD CHEM, V51, P323

[4] REPLICATION INHIBITION AND TRANSLESION SYNTHESIS ON TEMPLATES CONTAINING SITE-SPECIFICALLY PLACED CIS-DIAMMINEDICHLOROPLATINUM(II) DNA ADDUCTS [J].

COMESS, KM ;

BURSTYN, JN ;

ESSIGMANN, JM ;

LIPPARD, SJ .

BIOCHEMISTRY, 1992, 31 (16) :3975-3990

[5] CHARACTERIZATION OF A DNA DAMAGE-RECOGNITION PROTEIN FROM MAMMALIAN-CELLS THAT BINDS SPECIFICALLY TO INTRASTRAND D(GPG) AND D(APG) DNA ADDUCTS OF THE ANTICANCER DRUG CISPLATIN [J].

DONAHUE, BA ;

AUGOT, M ;

BELLON, SF ;

TREIBER, DK ;

TONEY, JH ;

LIPPARD, SJ ;

ESSIGMANN, JM .

BIOCHEMISTRY, 1990, 29 (24) :5872-5880

[6] Solution structure of a DNA duplex containing a nitroxide spin-labeled platinum d(GpG) intrastrand cross-link refined with NMR-derived long-range electron-proton distance restraints [J].

Dunham, SU ;

Turner, CJ ;

Lippard, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (22) :5395-5406

[7] MODEL COMPLEXES OF POSSIBLE CROSS-LINKING PRODUCTS OF CIS-PT(NH3)22+ WITH CYTOSINE AND GUANINE BASES OF DNA - X-RAY STRUCTURES OF 3 MIXED-LIGAND COMPLEXES OF CIS-DIAMMINEPLATINUM(II) WITH 1-METHYLCYTOSINE AND NEUTRAL AND ANIONIC 9-ETHYLGUANINE [J].

FAGGIANI, R ;

LIPPERT, B ;

LOCK, CJL ;

SPERANZINI, RA .

INORGANIC CHEMISTRY, 1982, 21 (08) :3216-3225

[8] AN UNEXPECTED G-G BASE-PAIRING CAUSED BY THE COORDINATION OF PLATINUM(II) AT THE N(7) POSITION OF 9-ETHYLGUANINE [J].

FAGGIANI, R ;

LOCK, CJL ;

LIPPERT, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (16) :5418-5419

[9] CHEMISTRY OF BIS(PLATINUM) COMPLEXES - FORMATION OF TRANS DERIVATIVES FROM TETRAAMINE COMPLEXES [J].

FARRELL, N ;

QU, Y .

INORGANIC CHEMISTRY, 1989, 28 (18) :3416-3420

[10] NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin [J].

Gelasco, A ;

Lippard, SJ .

BIOCHEMISTRY, 1998, 37 (26) :9230-9239

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