Anti-nociceptive effect of neuropeptide Y in periaqueductal grey in rats with inflammation

被引：23

作者：

Wang, JZ

Lundeberg, T

Yu, LC ^{[1
]}

机构：

[1] Peking Univ, Coll Life Sci, Dept Physiol, Beijing 100871, Peoples R China

[2] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden

[3] Karolinska Inst, Dept Rehabil Med, S-17177 Stockholm, Sweden

来源：

BRAIN RESEARCH | 2001年 / 893卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

hindpaw withdrawal latency; inflammation; periaqueductal grey; neuropeptide Y; Y1; receptor;

D O I：

10.1016/S0006-8993(00)03279-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experimental inflammation was induced by subcutaneous injection of carrageenan into the left hindpaw of rats. Intra-periaqueductal grey (PAG) injection of 0.02 or 0.1 nmol of neuropeptide Y (NPY), but not 0.004 nmol, induced significant increases in hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats with inflammation. Furthermore, the anti-nociceptive effect of NPY was blocked partly by following intra-PAG injection of the Y1 receptor antagonist NPY28-36. The results demonstrated that NPY plays an anti-nociceptive role in PAG in rats with inflammation, in which Y1 receptor is involved. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：264 / 267

页数：4

共 18 条

[1] NEUROPEPTIDE-Y DISTRIBUTION IN HUMAN-BRAIN [J].