Co-localization of 5-HT1B- and 5-HT1D receptor mRNA in serotonergic cell bodies in guinea pig dorsal raphe nucleus:: a double labeling in situ hybridization histochemistry study

被引：29

作者：

Bonaventure, P

Langlois, X

Leysen, JE

机构：

[1] Janssen Res Fdn, Dept Biochem Pharmacol, B-2340 Beerse, Belgium

[2] Grad Sch Neurosci Amsterdam, NL-1100 AA Amsterdam, Netherlands

来源：

NEUROSCIENCE LETTERS | 1998年 / 254卷 / 02期

关键词：

5-HT1B receptor; 5-HT1D receptor; 5-HT transporter; dorsal raphe; double labeling in situ hybridization; depression;

D O I：

10.1016/S0304-3940(98)00680-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to provide further details on the cellular localization of 5-HT1B- and 5-HT1D receptor mRNA in the dorsal raphe nucleus, we performed, in the same sections of guinea-pig dorsal raphe nucleus, double labeling in situ hybridization histochemistry for: (1) 5-HT1B receptor mRNA and 5-HT1D receptor mRNA, (2) 5-HT1B receptor mRNA and 5-HT transporter (5-HTT) mRNA as marker for serotonergic neurons and (3) 5-HT1D receptor mRNA and 5-HTT mRNA. The 5-HT1B receptor mRNA was present in all cells containing 5-HT1D receptor mRNA. Similarly, both 5-HT1B- and 5-HT1D receptor mRNA was present in all 5-HTT mRNA positive cells. The present study demonstrates that 5-HT1B- and 5-HT1D receptor mRNA is co-localized in serotonergic cell bodies of the guinea pig dorsal raphe nucleus. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：113 / 116

页数：4

共 21 条

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[Anonymous], [No title captured]

[2] SHORT-TERM LITHIUM TREATMENT ENHANCES RESPONSIVENESS OF POSTSYNAPTIC 5-HT1A RECEPTORS WITHOUT ALTERING 5-HT AUTORECEPTOR SENSITIVITY - AN ELECTROPHYSIOLOGICAL STUDY IN THE RAT-BRAIN [J].