TPGS-Functionalized Polydopamine-Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance

被引：289

作者：

Cheng, Wei ^{[1
,2
]}

Liang, Chaoyu ^{[1
,2
]}

Xu, Lv ^{[1
]}

Liu, Gan ^{[1
,3
]}

Gao, Nansha ^{[4
]}

Tao, Wei ^{[1
]}

Luo, Lingyan ^{[1
]}

Zuo, Yixiong ^{[1
]}

Wang, Xusheng ^{[1
]}

Zhang, Xudong ^{[1
]}

Zeng, Xiaowei ^{[1
,2
]}

Mei, Lin ^{[1
,3
]}

机构：

[1] Tsinghua Univ, Grad Sch Shenzhen, Div Life & Hlth Sci, Shenzhen 518055, Peoples R China

[2] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Guangdong, Peoples R China

[4] Shenzhen Univ, Coll Optoelect Engn, Shenzhen 518060, Peoples R China

来源：

SMALL | 2017年 / 13卷 / 29期

基金：

中国国家自然科学基金;

关键词：

VITAMIN-E TPGS; TARGETED CO-DELIVERY; SURFACE MODIFICATION; CONTROLLED-RELEASE; INSPIRED POLYDOPAMINE; CELLULAR UPTAKE; NANOPARTICLES; DOCETAXEL; CONJUGATION; DEPOSITION;

D O I：

10.1002/smll.201700623

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A nanocarrier system of D-a-tocopheryl polyethylene glycol 1000 succinate (TPGS)- functionalized polydopamine-coated mesoporous silica nanoparticles (NPs) is developed for sustainable and pH-responsive delivery of doxorubicin (DOX) as a model drug for the treatment of drug-resistant nonsmall cell lung cancer. Such nanoparticles are of desired particle size, drug loading, and drug release profile. The surface morphology, surface charge, and surface chemical properties are also successfully characterized by a series of techniques such as transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) method, thermal gravimetric analysis (TGA), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR). The normal A549 cells and drug-resistant A549 cells are employed to access the cytotoxicity and cellular uptake of the NPs. The therapeutic effects of TPGS-conjugated nanoparticles are evaluated in vitro and in vivo. Compared with free DOX and DOX-loaded NPs without TPGS ligand modification, MSNs-DOX@PDA-TPGS exhibits outstanding capacity to overcome multidrug resistance and shows better in vivo therapeutic efficacy. This splendid drug delivery platform can also be sued to deliver other hydrophilic and hydrophobic drugs.

引用

页数：12

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