Therapeutic effects of TACI-Ig on rats with adjuvant-induced arthritis via attenuating inflammatory responses

被引：74

作者：

Chang, Yan ^{[1
]}

Wu, Yujing ^{[1
]}

Wang, Di ^{[1
]}

Wei, Wei ^{[1
]}

Qin, Qiong ^{[1
]}

Xie, Guoxiong ^{[1
]}

Zhang, Lingling ^{[1
]}

Yan, Shangxue ^{[1
]}

Chen, Jingyu ^{[1
]}

Wang, Qingtong ^{[1
]}

Wu, Huaxun ^{[1
]}

Xiao, Feng ^{[1
]}

Sun, Wuyi ^{[1
]}

Jin, Juan ^{[1
]}

Wang, Wenxiang ^{[2
]}

机构：

[1] Anhui Med Univ, Educ Minist China, Key Lab Antiinflammatory & Immunopharmacol, Inst Clin Pharmacol, Hefei 230032, Peoples R China

[2] RC Biotechnol Ltd, Yantai, Peoples R China

来源：

RHEUMATOLOGY | 2011年 / 50卷 / 05期

基金：

中国国家自然科学基金;

关键词：

B lymphocyte stimulator; A proliferation-inducing antigen; TACI-Ig; Arthritis; Autoimmune; T cell; B-LYMPHOCYTE STIMULATOR; NECROSIS-FACTOR FAMILY; COLLAGEN-INDUCED ARTHRITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; T-CELL-ACTIVATION; TNF RECEPTOR; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASE; BONE DESTRUCTION; APRIL;

D O I：

10.1093/rheumatology/keq404

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Methods. Rats with experimental arthritis were randomly separated into different groups and then treated with TACI-Ig (0.7, 2.1, 6.3 mg/kg), rhTNFR-Fc (2.8 mg/kg), MTX (0.5 mg/kg) or IgG-Fc (6.3 mg/kg), from Day 16 to Day 34 after immunization. Arthritis was evaluated by hind paw swelling, polyarthritis index and histopathological examination. Activities of BLyS, APRIL, IL-1 beta, IL-2, IL-10, TGF-beta 1, PGE(2), TNF-alpha, IFN-gamma, immunoglobulin (Ig)G1, IgG2a, IgM and IgA were assessed by ELISA. Cluster of differentiation (CD)20 expression was detected by immunohistochemical analysis. Results. TACI-Ig (2.1, 6.3 mg/kg) treatment significantly reduced the severity of established arthritis using the methods of clinical observation and histopathological examination. TACI-Ig treatment inhibited expression of IgM, decreased the expression of BLyS and APRIL and regulated the balance of pro-inflammatory and anti-inflammatory cytokines in serum of AA rats. Immunohistochemical analysis demonstrated that CD20 production was reduced in spleen. Conclusions. Data presented here demonstrate that administration of TACI-Ig significantly attenuates progression of experimental arthritis, with reductions in inflammatory response and bone and joint destruction.

引用

页码：862 / 870

页数：9

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