Adamantylaminopyrimidines and -pyridines are potent inducers of tumor necrosis factor-α

被引：24

作者：

Kazimierczuk, Z

Górska, A

Switaj, T

Lasek, W

机构：

[1] Agr Univ Warsaw, Inst Chem, PL-02528 Warsaw, Poland

[2] Med Univ Warsaw, Biostruct Ctr, Dept Immunol, PL-02004 Warsaw, Poland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(01)00174-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of (1-adamantyl)aminopyrimidine and -pyridine derivatives was prepared by adamantyl cation attack on amino heterocycles. The adamantylated compounds. particularly 2-(1-adamantyl)amino-6-methylpyridine, were found to be potent TNF-alpha inducers in murine melanoma cells transduced with gene for human TNF-alpha. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1197 / 1200

页数：4

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