Re-identification of Aspergillus nidulans wA gene to code for a polyketide synthase of naphthopyrone

被引：112

作者：

Watanabe, A

Fujii, I

Sankawa, U

Mayorga, ME

Timberlake, WE

Ebizuka, Y ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

[3] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA

[4] Cereon Genom, LLC, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 01期

关键词：

biosynthesis; fungi; pigments; polyketides; pyrones;

D O I：

10.1016/S0040-4039(98)80027-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By reconstruction and expression of the full-length WA (NWA) polyketide synthase of A. nidulans based on the revised wA gene sequence, its product was re-identified to be a naphthopyrone compound YWA1 instead of citreoisocoumarin and its derivatives, which were found to be products of C-terminus truncated WA polyketide synthase. YWA1 shows yellow color and is considered to be a true intermediate of A, nidulans asexual spore pigments. Thus, the wA gene is identified to code for a polyketide synthase of heptaketide naphthopyrone YWA1. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：91 / 94

页数：4

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