Sex, Fat and the Tilt of the Earth: effects of sex and season on the feeding response to centrally administered leptin in sheep.

被引：48

作者：

Clarke, IJ

Tilbrook, AJ

Turner, AI

Doughton, BW

Goding, JW

机构：

[1] Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia

[2] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia

[3] Monash Univ, Sch Med, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

来源：

ENDOCRINOLOGY | 2001年 / 142卷 / 06期

关键词：

D O I：

10.1210/en.142.6.2725

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Whilst there have been many studies in various species examining the effects of leptin on food intake, there is a paucity of data comparing responsiveness in the two sexes. We have, therefore, addressed this issue in sheep. Because this species shows seasonal variation in voluntary food intake (VFI), we also considered the possibility that there might be seasonal variation in the responsivity to leptin. Centrally administered leptin was relatively ineffective as a satiety factor in either sex during Autumn. In Spring, leptin had a profound inhibitory effect on VFI in the females, but only a slight effect in males. These data indicate that responsiveness to leptin depends on sex and also on season in animals that are substantially affected by photoperiod.

引用

收藏

页码：2725 / 2728

页数：4

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