Increased proportion of HLA-class-I-specific natural killer cell receptors (CD94) on peripheral blood mononuclear cells after allogeneic bone marrow transplantation

被引：12

作者：

Tanaka, J

Tutumi, Y

Zhang, L

Mori, A

Kahata, K

Toyoshima, N

Ohta, S

Kobayashi, S

Hashino, S

Asaka, M

Imamura, M

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Hematol & Oncol, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Hokkaido Univ, Grad Sch Med, Dept Internal Med 3, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Transfus Med 3, Sapporo, Hokkaido, Japan

来源：

ACTA HAEMATOLOGICA | 2001年 / 105卷 / 02期

关键词：

bone marrow transplantation; CD94; graft versus host disease; graft versus leukemia; killer cell inhibitory receptor;

D O I：

10.1159/000046540

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the present study, we investigated the inhibitory natural killer cell receptor (NKR) expression of CD94/NKG2A on PBMC after allogeneic bone marrow transplantation (BMI). The proportion of CD94 expression on PBMC was higher in patients without chronic graft-versus-host disease (cGVHD) and also in cGVHD patients with good response to conventional immunosuppressive therapy than in cGVHD patients with poor response. Also, the proportions of CD94+/CD3+ cells and CD94+/CD8+ cells were higher in cGVHD patients showing good response. In addition, the proportion of NKG2A-expressing cells was higher in patients without cGVHD than in patients with cGVHD. Therefore, chronic allostimulation after allo-BMT may augment the proportion of CD94/NKG2A-positive cells, and these cells may play some role in the regulation of alloresponse in some patients, Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：89 / 91

页数：3

共 16 条

[1] Natural killer (NK)-cell function and antileukemic activity of a large population of CD3(+)/CD8(+) T cells expressing NK receptors for major histocompatibility complex class I after ''three-loci'' HLA-incompatible bone marrow transplantation [J].