Calcium signalling: Store-operated channel found at last

被引:21
作者
Petersen, OH [1 ]
Fedirko, NV [1 ]
机构
[1] Univ Liverpool, Physiol Lab, MRC, Secretory Control Res Grp, Liverpool L69 3BX, Merseyside, England
关键词
D O I
10.1016/S0960-9822(01)00309-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The intestinal Ca2+ transport protein CaT1 has recently been shown to have the biophysical characteristics of the Ca2+-release activated Ca2+ channel that refills internal Ca2+ stores following agonist-elicited release. This finding highlights a hitherto unrecognized link between epithelial Ca2+ transport and Ca2+ signalling.
引用
收藏
页码:R520 / R523
页数:4
相关论文
共 20 条
[1]   On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trp proteins [J].
Birnbaumer, L ;
Zhu, X ;
Jiang, MS ;
Boulay, G ;
Peyton, M ;
Vannier, B ;
Brown, D ;
Platano, D ;
Sadeghi, H ;
Stefani, E ;
Birnbaumer, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (26) :15195-15202
[2]   Single channel properties and regulated expression of Ca2+ release-activated Ca2+ (CRAC) channels in human T cells [J].
Fomina, AF ;
Fanger, CM ;
Kozak, JA ;
Cahalan, MD .
JOURNAL OF CELL BIOLOGY, 2000, 150 (06) :1435-1444
[3]   Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice [J].
Freichel, M ;
Suh, SH ;
Pfeifer, A ;
Schweig, U ;
Trost, C ;
Weissgerber, P ;
Biel, M ;
Philipp, S ;
Freise, D ;
Droogmans, G ;
Hofmann, F ;
Flockerzi, V ;
Nilius, B .
NATURE CELL BIOLOGY, 2001, 3 (02) :121-127
[4]   Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca2+ current ICRAC [J].
Gilabert, JA ;
Parekh, AB .
EMBO JOURNAL, 2000, 19 (23) :6401-6407
[5]   Energized mitochondria increase the dynamic range over which inositol 1,4,5-trisphosphate activates store-operated calcium influx [J].
Gilabert, JA ;
Bakowski, D ;
Parekh, AB .
EMBO JOURNAL, 2001, 20 (11) :2672-2679
[6]   Toward a comprehensive molecular model of active calcium reabsorption [J].
Hoenderop, JGJ ;
Willems, PHGM ;
Bindels, RJM .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2000, 278 (03) :F352-F360
[7]   Molecular identification of the apical Ca2+ channel in 1,25-dihydroxyvitamin D3-responsive epithelia [J].
Hoenderop, JGJ ;
van der Kemp, AWCM ;
Hartog, A ;
van de Graaf, SFJ ;
van Os, CH ;
Willems, PHGM ;
Bindels, RJM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) :8375-8378
[8]   Free [Ca2+] dynamics measured in agonist-sensitive stores of single living intact cells:: a new look at the refilling process [J].
Hofer, AM ;
Landolfi, B ;
Debellis, L ;
Pozzan, T ;
Curci, S .
EMBO JOURNAL, 1998, 17 (07) :1986-1995
[9]   Termination of cytosolic Ca2+ signals:: Ca2+ reuptake into intracellular stores is regulated by the free Ca2+ concentration in the store lumen [J].
Mogami, H ;
Tepikin, AV ;
Petersen, OH .
EMBO JOURNAL, 1998, 17 (02) :435-442
[10]   Store depletion and calcium influx [J].
Parekh, AB ;
Penner, R .
PHYSIOLOGICAL REVIEWS, 1997, 77 (04) :901-930