Long-term data storage in DNA

被引:93
作者
Cox, JPL [1 ]
机构
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
关键词
D O I
10.1016/S0167-7799(01)01671-7
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
This article discusses how DNA might be used to store data. It is argued that, at present, DNA would be best employed as a long-term repository (thousands or millions of years). How data-containing DNA might be packaged and how the data might be encrypted, with particular attention to the encryption of written information, is also discussed. Various encryption issues are touched on, such as how data-containing DNA m ig ht be differentiated from genetic material, error detection, data compression and reading frame location. Finally,this article broaches the difficulty of constructing very large pieces of DNA in the laboratory and highlights some complications that might arise when attempting to transmit DNA-encrypted data to recipients who are a long period of time in the future.
引用
收藏
页码:247 / 250
页数:4
相关论文
共 37 条
[1]  
BERMANT C, 1979, EBLA ARCHAEOLOGICAL, P70
[2]   In vitro cloning of complex mixtures of DNA on microbeads:: Physical separation of differentially expressed cDNAs [J].
Brenner, S ;
Williams, SR ;
Vermaas, EH ;
Storck, T ;
Moon, K ;
McCollum, C ;
Mao, JI ;
Luo, SJ ;
Kirchner, JJ ;
Eletr, S ;
DuBridge, RB ;
Burcham, T ;
Albrecht, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1665-1670
[3]   Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays [J].
Brenner, S ;
Johnson, M ;
Bridgham, J ;
Golda, G ;
Lloyd, DH ;
Johnson, D ;
Luo, SJ ;
McCurdy, S ;
Foy, M ;
Ewan, M ;
Roth, R ;
George, D ;
Eletr, S ;
Albrecht, G ;
Vermaas, E ;
Williams, SR ;
Moon, K ;
Burcham, T ;
Pallas, M ;
DuBridge, RB ;
Kirchner, J ;
Fearon, K ;
Mao, J ;
Corcoran, K .
NATURE BIOTECHNOLOGY, 2000, 18 (06) :630-634
[4]   CLONING OF LARGE SEGMENTS OF EXOGENOUS DNA INTO YEAST BY MEANS OF ARTIFICIAL CHROMOSOME VECTORS [J].
BURKE, DT ;
CARLE, GF ;
OLSON, MV .
SCIENCE, 1987, 236 (4803) :806-812
[5]   REVIVAL AND IDENTIFICATION OF BACTERIAL-SPORES IN 25-MILLION-YEAR-OLD TO 40-MILLION-YEAR-OLD DOMINICAN AMBER [J].
CANO, RJ ;
BORUCKI, MK .
SCIENCE, 1995, 268 (5213) :1060-1064
[6]  
CHADWICK J, 1967, DECIPHERMENT LINEAR, P40
[7]   Hiding messages in DNA microdots [J].
Clelland, CT ;
Risca, V ;
Bancroft, C .
NATURE, 1999, 399 (6736) :533-534
[8]   CODES WITHOUT COMMAS [J].
CRICK, FHC ;
GRIFFITH, JS ;
ORGEL, LE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1957, 43 (05) :416-421
[9]  
DAVIES WV, 2000, EGYPTIAN HIEROGLYPHS, P33
[10]   Improving the efficiency of the genetic code by varying the codon length - The perfect genetic code [J].
Doig, AJ .
JOURNAL OF THEORETICAL BIOLOGY, 1997, 188 (03) :355-360