The combination of oseltamivir with azithromycin does not show additional benefits over oseltamivir monotherapy in mice infected with influenza A(H1N1)pdm2009 virus

被引：8

作者：

Fage, Clement

Pizzorno, Andres

Rheaume, Chantal

Abed, Yacine

Boivin, Guy ^{[1
,2
]}

机构：

[1] CHUQ CHUL, Res Ctr Infect Dis, Room RC-709 2705 Blvd Laurier, Quebec City, PQ G1V 4G2, Canada

[2] Laval Univ, Room RC-709 2705 Blvd Laurier, Quebec City, PQ G1V 4G2, Canada

来源：

JOURNAL OF MEDICAL VIROLOGY | 2017年 / 89卷 / 12期

关键词：

azithromycin; H1N1; influenza; mouse; oseltamivir; MACROLIDE ANTIBIOTICS; EPITHELIAL-CELLS; CLARITHROMYCIN; SUSCEPTIBILITY; PROPAGATION; INHIBITION; RESPONSES;

D O I：

10.1002/jmv.24911

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The combination of azithromycin, an immunomodulator, with oseltamivir was compared to oseltamivir monotherapy in a lethal BALB/c model of influenza A(H1N1)pdm09 infection. Groups of 14-16 mice received oral oseltamivir (10 mg/kg once daily for 5 days, starting at day 2 post-inoculation) alone or combined to azithromycin (a single 100 mg/kg dose, injected intraperitoneally at day 3 post-inoculation). Based on survival rates, lung viral titers, and pro-inflammatory cytokine levels, the combination therapy did not provide obvious additional clinical/virological benefits over oseltamivir monotherapy. Additional studies are still needed to better define the potential role of adjunctive immunomodulatory therapy for severe influenza infections.

引用

页码：2239 / 2243

页数：5

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