Influence of obesity on bone density in postmenopausal women

被引:47
作者
Da Silva, Henyse G. Valente [1 ]
Mendonca, Laura M. C.
Conceicao, Flavia L. [1 ]
Zahar, Sivia E. V.
Farias, Maria Luaa F. [1 ]
机构
[1] Univ Fed Rio de Janeiro, HUCFF, Div Endocrinol, BR-21941 Rio De Janeiro, Brazil
关键词
menopause; estrogens; obesity; bone density; osteoporosis;
D O I
10.1590/S0004-27302007000600008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To evaluate the influence of obesity, age, and years since menopause on bone density. Methods: A retrospective analysis of bone mineral density (BMD) obtained from 588 women, 41 to 60 years, previously menopaused (1-10 years before). Results: Positive influence of obesity was confirmed by the significant differences in BMD at lumbar spine, femoral neck (FN), and trochanter (TR) between the groups (p < 0.01). Age and years since menopause (YSM) were negatively correlated with BMD at all sites (p = 0.000). Comparing patients within 1 to < 6 YSM versus 6 to 10 YSM, BMD was higher in the former at LS and FN (p < 0.005), despite the higher BMI in the older group (p = 0.01). Obese patients had a lower prevalence of osteoporosis at LS and FN (p = 0.009). Regression analysis identified BMI as the strongest determinant of FN and TR BMD, while YSM was the strongest determinant of LS BMD., Conclusion: The protective effect of obesity is overtaken by age and estradiol deficiency. We recommend that even obese postmenopausal women should be screened for osteoporosis.
引用
收藏
页码:943 / 949
页数:7
相关论文
共 48 条
[1]   Bone loss and bone size after menopause [J].
Ahlborg, HG ;
Johnell, O ;
Turner, CH ;
Rannevik, G ;
Karlsson, MK .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (04) :327-334
[2]  
Albala C, 1996, INT J OBESITY, V20, P1027
[3]  
Bachrach Laura K., 1993, Current Opinion in Pediatrics, V5, P467
[4]   Clinical evaluation for osteoporosis [J].
Becker, C .
CLINICS IN GERIATRIC MEDICINE, 2003, 19 (02) :299-+
[5]   Serum leptin level is a predictor of bone mineral density in postmenopausal women [J].
Blain, H ;
Vuillemin, A ;
Guillemin, F ;
Durant, R ;
Hanesse, B ;
De Talance, N ;
Doucet, B ;
Jeandel, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (03) :1030-1035
[6]   Amylin fasting plasma levels are decreased in patients with osteoporosis [J].
Bronsky, J ;
Prusa, R .
OSTEOPOROSIS INTERNATIONAL, 2004, 15 (03) :243-247
[7]  
CHRISTIANSEN C, 1994, OSTEOPOROSIS INT, V4, P47
[8]   Bone turnover and body weight relationships differ in normal-weight compared with heavier postmenopausal women [J].
Cifuentes, M ;
Johnson, MA ;
Lewis, RD ;
Heymsfield, SB ;
Chowdhury, HA ;
Modlesky, CM ;
Shapses, SA .
OSTEOPOROSIS INTERNATIONAL, 2003, 14 (02) :116-122
[9]   EFFECTS OF AGING AND OBESITY ON AROMATASE-ACTIVITY OF HUMAN ADIPOSE-CELLS [J].
CLELAND, WH ;
MENDELSON, CR ;
SIMPSON, ER .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 60 (01) :174-177
[10]  
CONNOR EB, 1995, AM J MAD, V98, pS3