The thiyl radical-mediated isomerization of cis-monounsaturated fatty acid residues in phospholipids:: a novel path of membrane damage?

被引:45
作者
Ferreri, C
Costantino, C
Landi, L
Mulazzani, QG
Chatgilialoglu, C
机构
[1] CNR, ICoCEA, I-40129 Bologna, Italy
[2] Univ Naples Federico II, Dipartimento Chim Organ & Biol, I-80134 Naples, Italy
[3] Univ Bologna, Dipartimento Biochim G Moruzzi, I-40126 Bologna, Italy
[4] CNR, FRAE, I-40129 Bologna, Italy
关键词
D O I
10.1039/a809674k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Thiyl radicals, generated from biologically relevant thiols under biomimetic conditions, reversibly attack the double bonds of unsaturated phospholipids containing cis-fatty acid residues either in lipid solutions or lipid vesicles, thus producing phospholipids containing trans-fatty acid residues in high yield.
引用
收藏
页码:407 / 408
页数:2
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