The thiyl radical-mediated isomerization of cis-monounsaturated fatty acid residues in phospholipids:: a novel path of membrane damage?

被引：45

作者：

Ferreri, C

Costantino, C

Landi, L

Mulazzani, QG

Chatgilialoglu, C

机构：

[1] CNR, ICoCEA, I-40129 Bologna, Italy

[2] Univ Naples Federico II, Dipartimento Chim Organ & Biol, I-80134 Naples, Italy

[3] Univ Bologna, Dipartimento Biochim G Moruzzi, I-40126 Bologna, Italy

[4] CNR, FRAE, I-40129 Bologna, Italy

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 05期

关键词：

D O I：

10.1039/a809674k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thiyl radicals, generated from biologically relevant thiols under biomimetic conditions, reversibly attack the double bonds of unsaturated phospholipids containing cis-fatty acid residues either in lipid solutions or lipid vesicles, thus producing phospholipids containing trans-fatty acid residues in high yield.

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收藏

页码：407 / 408

页数：2

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