Hydrangenone, a New Isoprenoid with an Unprecedented Skeleton from Salvia hydrangea

被引：49

作者：

Farimani, M. Moridi ^{[1
]}

Taheri, Salman ^{[2
]}

Ebrahimi, Samad N. ^{[1
,3
]}

Bahadori, M. Babak ^{[1
]}

Khavasi, Hamid R. ^{[4
]}

Zimmermann, Stefanie ^{[3
,5
]}

Brun, Reto ^{[5
]}

Hamburger, Matthias ^{[3
]}

机构：

[1] Shahid Beheshti Univ, Dept Phytochem, Med Plants & Drugs Res Inst, Tehran, Iran

[2] Chem & Chem Engn Res Ctr Iran, Tehran, Iran

[3] Univ Basel, Div Pharmaceut Biol, CH-4056 Basel, Switzerland

[4] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

[5] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 01期

关键词：

D O I：

10.1021/ol202953b

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was Isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectroscopic methods. The relative and absolute configuration of 1 was assigned by NOESY and X-ray crystallographic analysis and by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed in vitro antiplasmodial activity, with an IC50 value of 1.4 mu M against P. falciparum. A plausible biosynthetic pathway of 1 was also proposed.

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页码：166 / 169

页数：4

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