Swelling and mechanical properties of a temperature-sensitive dextran hydrogel and its bioseparation applications

被引：25

作者：

Dong, J ^{[1
]}

Chen, L ^{[1
]}

Ding, YM ^{[1
]}

Han, WJ ^{[1
]}

机构：

[1] Tianjin Polytech Univ, Sch Chem Engn & Mat Sci, Minist Educ, Key Lab Hollow Fiber Membrane Mat & Membrane Proc, Tianjin 300160, Peoples R China

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2005年 / 206卷 / 19期

关键词：

bioseparation; hydrogels; N-isopropylacrylamide; mechanical properties; temperature-sensitive;

D O I：

10.1002/macp.200500125

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A series of temperature-sensitive dextran hydrogels (poly(NIPA-co-GMA-Dex)) were synthesized by the copolymerization of glycidyl methacrylate-derivatized dextran (GMA-Dex) and N-isopropylacrylamide (NIPA) in aqueous solution. Their swelling and mechanical properties and bioseparation behaviors were studied. It is found that poly(NIPA-co-GMA-Dex) hydrogels simultaneously exhibit much better swelling and mechanical properties. The interactions between poly(NIPA-co-GMA-Dex) hydrogels and sodium dodecylsulfate (SDS), Rutin, and DL-alpha-alanine were different because of their different hydrophobic nature, polarity, and molecular structure, and obviously depend on the temperature: the mechanism is discussed. In addition, using poly(NIPA-co-GMA-Dex) hydrogels as the absorbents, gel-extraction separation experiments of dextran and BSA solutions showed that the separation ability of poly(NIPA-co-GMA-Dex) hydrogels obviously increased upon reaching the LCST.

引用

页码：1973 / 1980

页数：8

共 35 条

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