Effect of hyperglycemia on pyruvate dehydrogenase activity and energy metabolites during ischemia and reperfusion in gerbil brain

被引：19

作者：

Katayama, Y ^{[1
]}

Fukuchi, T ^{[1
]}

Mc Kee, A ^{[1
]}

Terashi, A ^{[1
]}

机构：

[1] Nippon Med Sch, Dept Internal Med 2, Bunkyo Ku, Tokyo 113, Japan

来源：

BRAIN RESEARCH | 1998年 / 788卷 / 1-2期

关键词：

hyperglycemia; pyruvate dehydrogenase; energy metabolism; ischemia;

D O I：

10.1016/S0006-8993(97)01565-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of hyperglycemia on brain pyruvate dehydrogenase (PDH) and metabolites (ATP, PCr, and lactate) were investigated at 20 min ischemia, 0, 20, and 60 min, and 4 h reperfusion. During reperfusion, PDH activities were suppressed corresponding to the poor recovery of ATP and PCr concentrations and the increase in lactate concentration in the hyperglycemic group, suggesting that preischemic hyperglycemia may impair metabolism by suppressing PDH activity. (C) 1998 Elsevier Science B.V.

引用

页码：302 / 304

页数：3

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