Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes

被引：35

作者：

Cui, M ^{[1
]}

Mester, Z ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Natl Measurement Stand, Ottawa, ON K1A 0R6, Canada

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2003年 / 17卷 / 14期

关键词：

D O I：

10.1002/rcm.1030

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrospray ionization mass spectrometry (ESI-MS) coupled to liquid chromatography (LC) has been applied to investigate cisplatin and its hydrated complexes. Three hydrolysis products were identified following incubation of cisplatin in aqueous solution: monohydrated species, dihydrated species and the hydroxo-bridged dimer, each of which exhibited characteristic mass spectrometric behavior. The technique was employed to investigate the time- and pH-dependent hydrolysis of cisplatin in aqueous solution. The results have demonstrated that LC/ESI-MS is a powerful technique for the analysis of Pt(II) complexes and for monitoring their hydrolysis reactions. Copyright (C) 2003 Crown in the right of Canada. Published by John Wiley Sons, Ltd.

引用

页码：1517 / 1527

页数：11

共 53 条

[1]

AGGARWAL SK, 1980, CANCER CHEMOTH PHARM, V4, P249

[2] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CIS-DICHLORODIAMMINEPLATINUM(II) IN PLASMA ULTRAFILTRATE [J].

AUGEY, V ;

COCIGLIO, M ;

GALTIER, M ;

YEAROO, R ;

PINSANI, V ;

BRESSOLLE, F .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1995, 13 (09) :1173-1178

[3]

BARNISTER SJ, 1983, J CHROMATOGR, V273, P301

[4]

BARNISTER SJ, 1977, CLIN CHEM, V23, P2258

[5] CHARACTERIZATION OF CISPLATIN-GLUTATHIONE ADDUCTS BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY - EVIDENCE FOR THEIR FORMATION IN-VITRO BUT NOT IN-VIVO AFTER CONCOMITANT ADMINISTRATION OF CISPLATIN AND GLUTATHIONE TO RATS AND CANCER-PATIENTS [J].

BERNAREGGI, A ;

TORTI, L ;

FACINO, RM ;

CARINI, M ;

DEPTA, G ;

CASETTA, B ;

FARRELL, N ;

SPADACINI, S ;

CESERANI, R ;

TOGNELLA, S .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 669 (02) :247-263

[6] A PT-195 AND N-15 NMR-STUDY OF THE ANTI-CANCER DRUG, CIS-DIAMMINEDICHLOROPLATINUM(II), AND ITS HYDROLYSIS AND OLIGOMERIZATION PRODUCTS [J].

BOREHAM, CJ ;

BROOMHEAD, JA ;

FAIRLIE, DP .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1981, 34 (03) :659-664

[7] CIS-PLATINUM(II) AMINE COMPLEXES - SOME STRUCTURE-ACTIVITY-RELATIONSHIPS FOR IMMUNOSUPPRESSIVE, NEPHROTOXIC AND GASTROINTESTINAL (SIDE) EFFECTS IN RATS [J].

BROOMHEAD, JA ;

FAIRLIE, DP ;

WHITEHOUSE, MW .

CHEMICO-BIOLOGICAL INTERACTIONS, 1980, 31 (01) :113-132

[8] Liquid chromatography mass spectrometry for the detection of platinum antineoplastic complexes [J].

Burns, RB ;

Burton, RW ;

Albon, SP ;

Embree, L .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1996, 14 (03) :367-372

[9] PHASE-I STUDIES WITH CARBOPLATIN AT THE ROYAL-MARSDEN-HOSPITAL [J].

CALVERT, AH ;

HARLAND, SJ ;

NEWELL, DR ;

SIDDIK, ZH ;

HARRAP, KR .

CANCER TREATMENT REVIEWS, 1985, 12 :51-57

[10]

CASETTA B, 1991, ATOM SPECTROSC, V12, P81

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