Modelling of anti-HSV activity of lactoferricin analogues using amino acid descriptors

被引：27

作者：

Jenssen, H

Gutteberg, TJ

LeJon, T ^{[1
]}

机构：

[1] Univ Tromso, Dept Chem, N-9037 Tromso, Norway

[2] Univ Hosp N Norway, Dept Med Microbiol, N-9038 Tromso, Norway

来源：

JOURNAL OF PEPTIDE SCIENCE | 2005年 / 11卷 / 02期

关键词：

lactoferricin; anti-viral activity; herpes simplex virus; heparan sulfate; quantitative structure-activity relationships; projections to latent structures;

D O I：

10.1002/psc.604

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herpes simplex virus (HSV) causes a number of diseases and new therapies are being pursued vigorously. Earlier studies have shown that modified peptides based on lactoferricins reduce HSV-1 and HSV-2 infection, and structure-activity studies indicate that the anti-viral activity correlates with the binding affinity for heparan sulphate and chondroitin sulphate. In this study it is shown that theoretically derived amino acid descriptors can be used to model the anti-viral activity of peptides, as well as other peptide proper-ties, even more accurately. Copyright (C) 2004 European Peptide Society and John Wiley Sons, Ltd.

引用

页码：97 / 103

页数：7

共 32 条

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ABOUDY Y, 1994, INT J PEPT PROT RES, V43, P573

[2] Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparan sulphate at the cell surface [J].