Severe delayed thrombocytopenia associated with abciximab (ReoPro) therapy

被引：23

作者：

Reddy, MS

Carmody, TJ

Kereiakes, DJ

机构：

[1] Wright State Univ, Dept Cardiol, Good Samaritan Hosp, Dayton, OH 45435 USA

[2] Univ Cincinnati, Coll Med, Div Cardiol, Cincinnati, OH USA

来源：

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS | 2001年 / 52卷 / 04期

关键词：

abciximab; thrombocytopenia; heparin;

D O I：

10.1002/ccd.1108

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute thrombocytopenia associated with abciximab therapy has been well described, although the exact mechanism remains obscure. We report a case of delayed severe thrombocytopenia associated with abciximab therapy for percutaneous coronary intervention that occurred following hospital discharge. The detection of this phenomenon is important as it may portend heightened risk for severe or profound thrombocytopenia on subsequent reexposure to abciximab therapy. (C) 2001 Wiley-Liss, Inc.

引用

页码：486 / 488

页数：3

共 10 条

[1]

Bazzino O, 1998, NEW ENGL J MED, V338, P1498

[2] Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb IIIa [J].

Bednar, B ;

Cook, JJ ;

Holahan, MA ;

Cunningham, ME ;

Jumes, PA ;

Bednar, RA ;

Hartman, GD ;

Gould, RJ .

BLOOD, 1999, 94 (02) :587-599

[3] USE OF A MONOCLONAL-ANTIBODY DIRECTED AGAINST THE PLATELET GLYCOPROTEIN IIB/IIIA RECEPTOR IN HIGH-RISK CORONARY ANGIOPLASTY [J].

CALIFF, RM ;

SHADOFF, N ;

VALETT, N ;

BATES, E ;

GALEANA, A ;

KNOPF, W ;

SHAFTEL, J ;

BENDER, MJ ;

AVERSANO, T ;

RAQUENO, J ;

GURBEL, P ;

COWFER, J ;

COHEN, M ;

CROSS, P ;

BITTL, J ;

EDDINGS, K ;

TAYLOR, M ;

DEROSA, K ;

HATTEL, L ;

COOPER, L ;

ESHELMAN, B ;

FINTEL, D ;

NIEMYSKI, P ;

KLEIN, L ;

KENNEDY, H ;

THORNTON, T ;

KEREIAKES, D ;

MARTIN, L ;

ANDERSON, L ;

HIGBY, N ;

ELLIS, S ;

BREZINA, K ;

GEORGE, B ;

CHAPEKIS, A ;

SMITH, D ;

ANWAR, A ;

GERBER, TL ;

PRITCHARD, GL ;

MYLER, R ;

SHAW, R ;

MURPHY, M ;

WARD, K ;

MADIGAN, NP ;

BLANKENSHIP, J ;

HALBERT, M ;

FLANAGAN, C ;

TANNENBAUM, M ;

POLICH, M ;

STEVENSON, C ;

TCHENG, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (14) :956-961

[4]

Curtis BR, 1998, BLOOD, V92, p181A

[5] Safe use of platelet GP IIb/IIIa inhibitors [J].

Ferguson, JJ ;

Kereiakes, DJ ;

Adgey, AAJ ;

Fox, KAA ;

Hillegass, WB ;

Pfisterer, M ;

Vassanelli, C .

AMERICAN HEART JOURNAL, 1998, 135 (04) :S77-S89

[6]

Hanrath P, 1997, CIRCULATION, V96, P1445

[7]

Simoons ML, 1997, LANCET, V349, P1429

[8]

Tcheng JE, 1997, LANCET, V349, P1422

[9]

TCHENG JE, IN PRESS CIRCULATION

[10]

Topol EJ, 1997, NEW ENGL J MED, V336, P1689

← 1 →