Role of T antigen interactions with p53 in tumorigenesis

被引：167

作者：

Pipas, JM ^{[1
]}

Levine, AJ

机构：

[1] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA

[2] Rockefeller Univ, New York, NY 10021 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2001年 / 11卷 / 01期

关键词：

SV40; large T antigen; tumor suppressor; p53; tumorigenesis;

D O I：

10.1006/scbi.2000.0343

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

SV40 induces neoplastic transformation by disabling several hey cellular growth regulatory circuits. Among these are the Rb- and p53-families of tumor suppressors. The multifunctional, virus-encoded large T antigen blocks the function of both Rb and p53. Large T antigen uses multiple mechanisms to block p53 activity, and this action contributes to tumorigenesis, in part, by blocking p53-mediated growth suppression and apoptosis. Since the p53 pathway is inactivated in most human tumors, T antigen/p53 interactions offer a possible mechanism by which SV40 contributes to human cancer.

引用

页码：23 / 30

页数：8

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