Fructose-1,6-bisphosphate aldolase and transketolase: Complementary tools for the de novo syntheses of monosaccharides and analogues

被引:18
作者
Andre, C [1 ]
Demuynck, C [1 ]
Gefflaut, T [1 ]
Guerard, C [1 ]
Hecquet, L [1 ]
Lemaire, M [1 ]
Bolte, J [1 ]
机构
[1] Univ Clermont Ferrand 2, Dept Chim, UMR 6504 SEESIB, F-63177 Clermont Ferrand, France
关键词
carbon-carbon bend; bromoacetol phosphate; unnatural sugars;
D O I
10.1016/S1381-1177(98)00014-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This paper reports a new synthesis of bromoacetol phosphate and dihydroxyacetone phosphate for use in fructose-1,6-bisphosphate aldolase (FB-aldolase) catalyzed syntheses. Then the activities of FB-aldolase and transketolase towards polyhydroxybutanal analogues of erythrose and erythrose-4-phosphate were studied. These activities were high enough to allow the syntheses of rare heptulose-1 -phosphates of the D and L series. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:113 / 118
页数:6
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