Actinonin induces apoptosis in U937 leukemia cells

被引：11

作者：

Grujic, M

Zavasnik-Bergant, T

Pejler, G

Renko, M

机构：

[1] Swedish Univ Agr Sci, Dept Mol Biosci, BMC, S-75123 Uppsala, Sweden

[2] Jozef Stefan Inst, Dept Biochem & Mol Biol, SI-1000 Ljubljana, Slovenia

[3] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana, Slovenia

来源：

CANCER LETTERS | 2005年 / 223卷 / 02期

关键词：

actinonin; apoptosis; leukemia;

D O I：

10.1016/j.canlet.2004.10.048

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have previously shown that actinonin causes inhibition of cellular proliferation in U937 leukemia cells. In this report we demonstrate that the inhibition of cell growth by actinonin occurs through the induction of apoptosis. Signs of apoptosis at high actinonin concentration included DNA fragmentation, exposure of phosphatidylserine and condensation of cell nuclei. Apoptosis caused by actinonin was inhibited by Z-VAD-FMK, a broad specificity inhibitor of caspases, implicating the caspase pathway of apoptosis. Further, apoptosis was associated with a large increase in intracellular caspase-3 and -7 activities. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：211 / 218

页数：8

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