Pancreatic tumors show high levels of hypoxia

被引：525

作者：

Koong, AC

Mehta, VK

Le, QT

Fisher, GA

Terris, DJ

Brown, JM

Bastidas, AJ

Vierra, M

机构：

[1] Stanford Univ, Med Ctr, Dept Radiat Oncol, Stanford, CA 94305 USA

[2] Stanford Univ, Med Ctr, Dept Med, Stanford, CA 94305 USA

[3] Stanford Univ, Med Ctr, Dept Otolaryngol, Stanford, CA 94305 USA

[4] Stanford Univ, Med Ctr, Dept Surg, Stanford, CA 94305 USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2000年 / 48卷 / 04期

关键词：

hypoxia; oxygenation; pancreas; adenocarcinoma;

D O I：

10.1016/S0360-3016(00)00803-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors, Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode, Results: All 7 tumors demonstrated significant tumor hypoxia, In contrast, adjacent normal pancreas shelved normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers. (C) 2000 Elsevier Science Inc.

引用

页码：919 / 922

页数：4

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