The Role of the Cerebellum in Cognition and Emotion: Personal Reflections Since 1982 on the Dysmetria of Thought Hypothesis, and Its Historical Evolution from Theory to Therapy

被引:475
作者
Schmahmann, Jeremy D. [1 ,2 ]
机构
[1] Massachusetts Gen Hosp, Dept Neurol, Lab Neuroanat & Cerebellar Neurobiol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
关键词
Cerebrocerebellar system; Cerebellar cognitive affective syndrome; Ataxia; Behavior; Psychosis; Schizophrenia; Autism; History; SUPERIOR TEMPORAL REGION; INFERIOR PARIETAL LOBULE; EXERCISE-BASED TREATMENT; DEEP BRAIN-STIMULATION; POSTERIOR-FOSSA TUMORS; ATAXIA RATING-SCALE; RHESUS-MONKEY; BASIS PONTIS; CORTICOPONTINE PROJECTION; PREFRONTAL CORTEX;
D O I
10.1007/s11065-010-9142-x
中图分类号
B849 [应用心理学];
学科分类号
040203 [应用心理学];
摘要
The cognitive neuroscience of the cerebellum is now an established multidisciplinary field of investigation. This essay traces the historical evolution of this line of inquiry from an emerging field to its current status, with personal reflections over almost three decades on this journey of discovery. It pays tribute to early investigators who recognized the wider role of the cerebellum beyond motor control, traces the origins of new terms and concepts including the dysmetria of thought theory, the universal cerebellar transform, and the cerebellar cognitive affective syndrome, and places these developments within the broader context of the scientific efforts of a growing community of cerebellar cognitive neuroscientists. This account considers the converging evidence from theoretical, anatomical, physiological, clinical, and functional neuroimaging approaches that have resulted in the transition from recognizing the cerebellar incorporation into the distributed neural circuits subserving cognition and emotion, to a hopeful new era of treatment of neurocognitive and neuropsychiatric manifestations of cerebellar diseases, and to cerebellar-based interventions for psychiatric disorders.
引用
收藏
页码:236 / 260
页数:25
相关论文
共 207 条
[1]
ABBIE AA, 1934, P ROY SOC LOND B BIO
[2]
ALBUS J S, 1971, Mathematical Biosciences, V10, P25, DOI 10.1016/0025-5564(71)90051-4
[3]
Efficacy of slow repetitive transcranial magnetic stimulation in the treatment of resistant auditory hallucinations in schizophrenia: A meta-analysis [J].
Aleman, Andre ;
Sommer, Iris E. ;
Kahn, Rene S. .
JOURNAL OF CLINICAL PSYCHIATRY, 2007, 68 (03) :416-421
[4]
CEREBROCEREBELLAR COMMUNICATION SYSTEMS [J].
ALLEN, GI ;
TSUKAHARA, N .
PHYSIOLOGICAL REVIEWS, 1974, 54 (04) :957-1006
[5]
Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry [J].
Andreasen, NC ;
OLeary, DS ;
Cizadlo, T ;
Arndt, S ;
Rezai, K ;
Ponto, LLB ;
Watkins, GL ;
Hichwa, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9985-9990
[6]
Angevine J.B., 1961, HUMAN CEREBELLUM ATL
[7]
[Anonymous], 1838, On the functions of the cerebellum
[8]
[Anonymous], 2006, FIBER PATHWAYS BRAIN, DOI DOI 10.1093/ACPROF:OSO/9780195104233.003.0014
[9]
[Anonymous], NEUROLOGY
[10]
[Anonymous], 2004, HUMAN NERVOUS SYSTEM, DOI DOI 10.1016/B978-012547626-3/50012-0