Efflux pump inhibitors in bacteria

被引：11

作者：

Alibert, Sandrine ^{[1
]}

Pages, Jean-Marie ^{[1
]}

机构：

[1] Univ Aix Marseille 2, Fac Med & Pharm, UMR MD1 Enveloppe Bacterienne Permeabilite & Anti, F-13385 Marseille 05, France

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2007年 / 17卷 / 08期

关键词：

antibiotics; efflux pumps; inhibitors; multi-drug resistance;

D O I：

10.1517/13543776.17.8.883

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The efficacy of antibiotherapy of infectious diseases is strongly compromised by the advent and spread of antibiotic resistance. Active efflux of cytotoxic drugs mediated by multi-drug transporters is the basis of multi-drug resistance in prokaryotic cells. Thus, inhibition of efflux pumps appears to be a promising strategy to combat multi-drug resistance pathogens. Different classes of inhibitors structurally unrelated have been patented in the last decade.

引用

页码：883 / 888

页数：6

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