Autophagosomes: biogenesis from scratch?

被引:225
作者
Reggiori, F
Klionsky, DJ [1 ]
机构
[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA
关键词
D O I
10.1016/j.ceb.2005.06.007
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
To survive extreme environmental conditions, and in response to certain developmental and pathological situations, eukaryotic organisms employ the catabolic process of autophagy. This degradative pathway allows cells to eliminate large portions of the cytoplasm, from aberrant protein aggregates to superfluous or damaged organelles and even entire organisms such as invading bacteria. Structures targeted for destruction are sequestered into large double-membrane vesicles called autophagosomes and then delivered into the interior of the lysosome or vacuole, where they are consumed by resident hydrolases. Autophagosome formation during selective autophagy is dependent upon the cargoes, and in all cases seems to involve expansion of the sequestering membrane.
引用
收藏
页码:415 / 422
页数:8
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