Genetic control of hepatitis A severity and susceptibility to allergy

被引：12

作者：

Chatenoud, Lucienne ^{[2
]}

Bach, Jean-Francois ^{[1
,2
]}

机构：

[1] Hop Necker Enfants Malad, INSERM, U1013, F-75015 Paris, France

[2] Univ Paris 05, INSERM, Paris, France

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 03期

关键词：

T-CELLS; AUTOIMMUNE; INFECTION; DISEASES; HYPERREACTIVITY; IDENTIFICATION; CYTOTOXICITY; PREVENTS; ASTHMA; MODEL;

D O I：

10.1172/JCI46418

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Hepatitis A virus (HAV) usually results in asymptomatic infection or mild disease, but in a small subset of patients it can lead to severe disease and even liver failure. In this issue of the fa, Kim et al. identify a polymorphism associated with this increased disease risk in the gene that encodes the HAV receptor - TIM1. Importantly, this TIM1 gene polymorphism protects from the development of atopic diseases in HAV-seropositive individuals.

引用

页码：848 / 850

页数：3

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