Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines

被引：69

作者：

Dang, Zhao

Yang, Yushe ^{[1
]}

Ji, Ruyun

Zhang, Shuhua

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Sichuan Ind Inst Antibiot, Chengdu 610051, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 16期

关键词：

fluoroquinolone; antibacterial activity; piperidine;

D O I：

10.1016/j.bmcl.2007.05.093

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design and synthesis of new fluoroquinolone antibacterial agents having substituted piperidine rings at the C-7 position are described. Most of the new compounds demonstrated high in vitro antibacterial activity. Several of them exhibited significant activities against Gram-positive organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4523 / 4526

页数：4

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