Direct organocatalytic de novo synthesis of carbohydrates

被引：212

作者：

Enders, D ^{[1
]}

Grondal, C ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen Klinikum, Inst Organ Chem, D-52074 Aachen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 08期

关键词：

aldol reaction; amino sugars; asymmetric synthesis; carbohydrates; organocatalysis;

D O I：

10.1002/anie.200462428

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One small step for a catalyst: A biomimetic asymmetric synthesis of carbohydrates was accomplished by a proline-catalyzed aldol reaction of 2,2-dimethyl-1,3-dioxan-5-one as the methylene component with various aldehydes. This new organocatalytic C3+Cn strategy leads directly to selectively protected simple sugars and amino sugars. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1210 / 1212

页数：3

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