Safety of measles, mumps and rubella vaccination in juvenile idiopathic arthritis

被引：74

作者：

Heijstek, Marloes W. ^{[1
]}

Pileggi, Gecilmara C. S. ^{[1
]}

Zonneveld-Huijssoon, Evelien ^{[1
]}

Armbrust, Wineke ^{[1
]}

Hoppenreijs, Esther P. A. H. ^{[1
]}

Uiterwaal, Cuno S. P. M. ^{[1
]}

Kuis, Wietse ^{[1
]}

Wulffraat, Nico M. ^{[1
]}

机构：

[1] Univ Utrecht, Med Ctr, Wilhelmina Childrens Hosp, Dept Paediat Immunol,Julius Ctr Hlth Sci & Primar, NL-3508 AB Utrecht, Netherlands

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2007年 / 66卷 / 10期

关键词：

D O I：

10.1136/ard.2006.063586

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To assess the effect of measles, mumps and rubella (MMR) vaccination on disease activity in children with juvenile idiopathic arthritis (JIA). Methods: A retrospective observational multicentre cohort study was performed in 314 patients with JIA, born between 1989 and 1996. Disease activity and medication use were compared during the period of 6 months before vaccination versus 6 months after vaccination. Disease activity was measured by joint counts, the Physician's global assessment scale and erythrocyte sedimentation rate. Next, we compared disease activity in patients vaccinated between 8 and 9 years of age with the activity in patients who had not been vaccinated at this time ( who received MMR between the ages of 9 and 10 years). Results: No increase in disease activity or medication use was seen in the 6 months after MMR vaccination (n = 207), including in patients using methotrexate ( n = 49). No overt measles infections were noted. When disease activity in vaccinated patients ( n = 108) was compared with activity in those not yet vaccinated ( n = 86), there were no significant differences. Conclusions: The MMR booster vaccination does not seem to aggravate disease activity in JIA. This indicates that the most patients with JIA can be vaccinated safely with the MMR vaccine. A prospective study is recommended.

引用

页码：1384 / 1387

页数：4

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