Targeted Metabolomics for Biomarker Discovery

被引：285

作者：

Griffiths, William J. ^{[2
]}

Koal, Therese ^{[1
]}

Wang, Yuqin ^{[2
]}

Kohl, Matthias ^{[3
]}

Enot, David P. ^{[1
]}

Deigner, Hans-Peter ^{[1
]}

机构：

[1] BIOCRATES Life Sci AG, A-6020 Innsbruck, Austria

[2] Univ Coll Swansea, Inst Mass Spectrometry, Sch Med, Swansea SA2 8PP, W Glam, Wales

[3] Univ Bayreuth, Dept Math, D-95440 Bayreuth, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 32期

关键词：

biomarker; lipidomics; mass spectrometry; metabolomics; multivariate statistics; CONGENITAL ADRENAL-HYPERPLASIA; TANDEM MASS-SPECTROMETRY; ADVERSE DRUG-REACTIONS; INBORN-ERRORS; CEREBROSPINAL-FLUID; ELECTROSPRAY-IONIZATION; SYSTEMS BIOLOGY; BILE-ACIDS; CHOLESTEROL HOMEOSTASIS; FUNCTIONAL-CHARACTERIZATION;

D O I：

10.1002/anie.200905579

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

M etabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and molecular diagnostics and requires bioinformatics and multivariate statistics. While successfully established in the screening of inborn errors in neonates, metabolomics is now widely used in the characterization and diagnostic research of an ever increasing number of diseases. In this Review we highlight important technical prerequisites as well as recent developments in metabolomics and metabolomics data analysis with special emphasis on their utility in biomarker identification and qualification, as well as targeted metabolomics by employing high-throughput mass spectrometry. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5426 / 5445

页数：20

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