Mineralocorticoid receptor splice variants in different human tissues

被引：22

作者：

Wickert, L ^{[1
]}

Watzka, M ^{[1
]}

Bolkenius, U ^{[1
]}

Bidlingmaier, F ^{[1
]}

Ludwig, M ^{[1
]}

机构：

[1] Univ Bonn, Dept Clin Biochem, D-53105 Bonn, Germany

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 1998年 / 138卷 / 06期

关键词：

D O I：

10.1530/eje.0.1380702

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mineralocorticoid receptor (MR), a member of the steroid receptor family, acts as a transcription factor and mediates both aldosterone and cortisol effects. Aldosterone specificity in some tissues results from the inactivation of competing cortisol into cortisone by 11 beta-hydroxysteroid dehydrogenase. In other tissues MR and the glucocorticoid receptor show overlapping physiological effects or may act together by forming a heterodimer. An additional MR splice variant (MR+4) has been found in different mRNA samples from rat tissues and human white blood cells, thereby implying additional modes of MR-regulated effects. We therefore looked for the presence of these two MR-mRNA isoforms in human classical aldosterone target tissues and various other tissues. MR-mRNA was found in all samples investigated, thereby showing the expression of MR to be more abundant than has been observed thus far. In addition, the MR+4-mRNA variant was also found in all the tissues examined.

引用

页码：702 / 704

页数：3

共 12 条

[1] CLONING OF HUMAN MINERALOCORTICOID RECEPTOR COMPLEMENTARY-DNA - STRUCTURAL AND FUNCTIONAL KINSHIP WITH THE GLUCOCORTICOID RECEPTOR [J].