The Sf1-related nuclear hormone receptor Hr39 regulates Drosophila female reproductive tract development and function

被引:97
作者
Allen, Anna K. [1 ]
Spradling, Allan C. [1 ]
机构
[1] Carnegie Inst Washington, Howard Hughes Med Inst, Dept Embryol, Baltimore, MD 21218 USA
来源
DEVELOPMENT | 2008年 / 135卷 / 02期
关键词
Hr39; spermathecae; reproductive tract; SF1 (NR5A1); steroid hormone;
D O I
10.1242/dev.015156
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The vertebrate nuclear hormone receptor steroidogenic factor 1 (SF1; NR5A1) controls reproductive development and regulates the transcription of steroid-modifying cytochrome P450 genes. We find that the SF1-related Drosophila nuclear hormone receptor HR39 is also essential for sexual development. In Hr39 mutant females, the sperm-storing spermathecae and glandular parovaria are absent or defective, causing sterility. Our results indicate that spermathecae and parovaria secrete reproductive tract proteins required for sperm maturation and function, like the mammalian epididymis and female reproductive tract. Hr39 controls the expression of specific cytochrome P450 genes and is required in females both to activate spermathecal secretion and repress male-specific courtship genes such as takeout. Thus, a pathway that, in vertebrates, controls sex-specific steroid hormone production, also mediates reproductive functions in an invertebrate. Our findings suggest that Drosophila can be used to model more aspects of mammalian reproductive biology than previously believed.
引用
收藏
页码:311 / 321
页数:11
相关论文
共 43 条
[1]  
ANDERSON RC, 1945, GENETICS, V30, P280
[2]   A genomic analysis of Drosophila somatic sexual differentiation and its regulation [J].
Arbeitman, MN ;
Fleming, AA ;
Siegal, ML ;
Null, BH ;
Baker, BS .
DEVELOPMENT, 2004, 131 (09) :2007-2021
[3]   THE ISOLATION AND CHARACTERIZATION OF DROSOPHILA YOLK PROTEIN GENES [J].
BARNETT, T ;
PACHL, C ;
GERGEN, JP ;
WENSINK, PC .
CELL, 1980, 21 (03) :729-738
[4]   ROLE OF SPERMATHECAE IN SPERM UTILIZATION AND STIMULATION OF OOGENESIS IN DROSOPHILA-MELANOGASTER [J].
BOULETREAUMERLE, J .
JOURNAL OF INSECT PHYSIOLOGY, 1977, 23 (09) :1099-1104
[5]   THE FOLLICLE CELLS ARE A MAJOR SITE OF VITELLOGENIN SYNTHESIS IN DROSOPHILA-MELANOGASTER [J].
BRENNAN, MD ;
WEINER, AJ ;
GORALSKI, TJ ;
MAHOWALD, AP .
DEVELOPMENTAL BIOLOGY, 1982, 89 (01) :225-236
[6]  
Buszczak M, 1999, DEVELOPMENT, V126, P4581
[7]  
Carney GE, 2000, GENETICS, V154, P1203
[8]   Using FlyAtlas to identify better Drosophila melanogaster models of human disease [J].
Chintapalli, Venkateswara R. ;
Wang, Jing ;
Dow, Julian A. T. .
NATURE GENETICS, 2007, 39 (06) :715-720
[9]  
Cooper T., 2006, Searching for Shakespeare, P72, DOI DOI 10.1017/CBO9780511545115.005
[10]   A Balbiani body and the fusome mediate mitochondrial inheritance during Drosophila oogenesis [J].
Cox, RT ;
Spradling, AC .
DEVELOPMENT, 2003, 130 (08) :1579-1590