Protein translocation: Checkpoint role for SRP GTPase activation

被引：10

作者：

Bange, Gert ^{[1
]}

Wild, Klemens ^{[1
]}

Sinning, Irmgard ^{[1
]}

机构：

[1] Univ Heidelberg, Biochem Ctr, INF328, D-69120 Heidelberg, Germany

来源：

CURRENT BIOLOGY | 2007年 / 17卷 / 22期

关键词：

D O I：

10.1016/j.cub.2007.09.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Co-translational protein targeting by the signal recognition particle (SOD) relies on a complex series of structural rearrangements in the SRP and its receptor (SR). In order to precisely coordinate the individual steps, the GTPases of the SRP and the SR form a unique complex in which GTP hydrolysis is activated in a composite active site. A recent study provides new insights on the link between the GTPases and protein translocation.

引用

页码：R980 / R982

页数：3

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