Triggering Receptor Expressed on Myeloid Cell 1

被引：46

作者：

Barraud, Damien ^{[1
]}

Gibot, Sebastien ^{[1
]}

机构：

[1] Univ Hosp Nancy, Med ICU, F-54000 Nancy, France

来源：

CRITICAL CARE CLINICS | 2011年 / 27卷 / 02期

关键词：

Sepsis; Infection; Innate immunity; TREM-1; Soluble TREM-1; VENTILATOR-ASSOCIATED PNEUMONIA; COMMUNITY-ACQUIRED PNEUMONIA; TOLL-LIKE RECEPTOR; INFLAMMATORY RESPONSES; ANTIINFLAMMATORY MEDIATOR; ISCHEMIA-REPERFUSION; BACTERIAL-INFECTION; PATHWAY MODULATION; ACUTE-PANCREATITIS; PLEURAL EFFUSION;

D O I：

10.1016/j.ccc.2010.12.006

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Sepsis is a common cause of morbidity and mortality in intensive care units. There is no gold standard for diagnosing sepsis because clinical and laboratory signs are neither sensitive nor specific enough and microbiological studies often show negative results. The triggering receptor expressed on myeloid cell 1 (TREM-1) is a member of the immunoglobulin superfamily. Its expression is upregulated on phagocytic cells in the presence of bacteria or fungi. This article reports on the potential usefulness of the assessment of the soluble form of TREM-1 in biologic fluids in the diagnosis of infection.

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页码：265 / +

页数：16

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