Structural analysis of human natural resistance-associated macrophage protein 1 promoter

被引：12

作者：

Kishi, F ^{[1
]}

Tanizawa, Y ^{[1
]}

Nobumoto, M ^{[1
]}

机构：

[1] YAMAGUCHI UNIV, SCH MED, DEPT INTERNAL MED, UBE, YAMAGUCHI 755, JAPAN

来源：

MOLECULAR IMMUNOLOGY | 1996年 / 33卷 / 03期

关键词：

natural resistance; NRAMP1; promoter; DNA sequence;

D O I：

10.1016/0161-5890(95)00144-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural resistance-associated macrophage protein gene 1 (Nramp1) was isolated as a candidate for the mouse gene locus Lsh/Ity/Bcg, which regulates macrophage activation for antimicrobial activity against intracellular pathogens. To investigate the structural and functional organization of the human homologue, NRAMP1, the overlapping genomic clones encompassing NRAMP1 were isolated. These clones spanned approximately 35 kb in size and the nucleotide sequence of 3779 bp of the 5' flanking region has been determined. The transcription start site was mapped by primer extension analysis. A TATA box element and the transcription regulatory elements in the acute phase reaction were found. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：265 / 268

页数：4

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