p53-independent inhibition of nitric oxide generation by cancer preventive interventions in ex vivo mouse peritoneal macrophages

被引：20

作者：

Mei, JJM ^{[1
]}

Hursting, SD ^{[1
]}

Perkins, SN ^{[1
]}

Phang, JM ^{[1
]}

机构：

[1] NCI, Lab Nutrit & Mol Regulat, Div Basic Sci, Frederick, MD 21702 USA

来源：

CANCER LETTERS | 1998年 / 129卷 / 02期

关键词：

p53; nitric oxide; calorie restriction; DHEA; cancer prevention;

D O I：

10.1016/S0304-3835(98)00102-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have previously reported that dietary interventions with purported anti-inflammatory activity delay spontaneous tumorigenesis in p53-deficient (p53(-/-)) mice. In the present study, 4 weeks of calorie restriction or the dietary administration of chemopreventive steroids dehydroepiandrosterone and 16 alpha-fluoro-5-androsten-17-one significantly reduced the inducible generation of nitric oxide (NO) in ex vivo peritoneal macrophages from male p53 wild-type and p53(-/-) mice relative to the respective ad libitum-fed controls; expression of inducible nitric oxide synthase II (NOS2) protein was also markedly decreased compared with respective controls. These findings suggest that the p53-independent suppression of inducible NO production observed in this study may contribute to the anti-cancer effects of these preventive interventions in p531(-/-) mice. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：191 / 197

页数：7

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