Reduction in multiresistant nosocomial infections in neonates following substitution of ceftazidime with piperacillin/tazobactam in empiric antibiotic therapy

被引：15

作者：

Flidel-Rimon, O

Friedman, S

Gradstein, S

Bardenstein, R

Shinwell, ES

机构：

[1] Hebrew Univ Jerusalem, Kaplan Med Ctr, Dept Neonatol, IL-76100 Rehovot, Israel

[2] Hebrew Univ Jerusalem, Kaplan Med Ctr, Div Pediat Infect Dis, IL-76100 Rehovot, Israel

[3] Hebrew Univ Jerusalem, Kaplan Med Ctr, Dept Microbiol, IL-76100 Rehovot, Israel

来源：

ACTA PAEDIATRICA | 2003年 / 92卷 / 10期

关键词：

multidrug-resistant Klebsiella; nosocomial infection; piperacillin/tazobactam; 3rd generation cephalosporins;

D O I：

10.1080/08035250310005297

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim: To evaluate the effect of a change in antibiotic protocol on pathogens that cause neonatal sepsis. Methods: Suspected sepsis was treated with amikacin together with ceftazidime in 1995 1998 and piperacillin/tazobactam in 1999-2002. Results: The annual rate for Klebsiella sepsis fell from 2.5 to 0.45 cases per 1000 admission days (p = 0.0001) between the two periods studied. Conclusion: The change from ceftazidime to piperacillin/tazobactam is associated with a decrease in the incidence of Klebsiella sepsis.

引用

页码：1205 / 1207

页数：3

共 9 条

[1] Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: A national survey [J].