Sudden hearing loss in a patient hepatitis C virus (HCV) positive on therapy with alpha-interferon: a possible autoimmune-microvascular pathogenesis

被引：23

作者：

Cadoni, G

Marinelli, L

De Santis, A

Romito, A

Manna, R

Ottaviani, F

机构：

[1] Univ Cattolica Sacro Cuore, Inst Otolaryngol, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dept Internal Med, I-00168 Rome, Italy

来源：

JOURNAL OF LARYNGOLOGY AND OTOLOGY | 1998年 / 112卷 / 10期

关键词：

hearing loss; sensorineural; Interferon; alpha; endothelium; antibody formation;

D O I：

10.1017/S0022215100142197

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Alpha interferon (alpha-IFN) is used for the treatment of various systemic disorders. Side-effects of alpha-IFN therapy can involve numerous organ systems, but sudden bearing loss has only once been recorded. We report a case of sudden hearing loss occurring in a patient with chronic hepatitis C treated with alpha-IFN and recovered five days after the discontinuation of this agent. This is the first record of anti-endothelial cell antibodies detection in a patient with sudden hearing loss. The finding of anti-endothelial cell antibodies suggests an association between sudden hearing loss and microvascular damage during interferon therapy.

引用

页码：962 / 963

页数：2

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