Recent advances in the total synthesis of piperidine and pyrrolidine natural alkaloids with ring-closing metathesis as a key step

被引：494

作者：

Felpin, FX ^{[1
]}

Lebreton, J ^{[1
]}

机构：

[1] CNRS, UMR 6513, Fac Sci & Tech, Synth Organ Lab, F-44322 Nantes 3, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 19期

关键词：

alkaloids; cyclization; metathesis; total synthesis;

D O I：

10.1002/ejoc.200300193

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This microreview focuses on recent applications of the ring-closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids. The most recent examples are described, from simple piperidine alkaloids to complex pentacyclic structures such as (+)-tabersonine. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

引用

页码：3693 / 3712

页数：20

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