Prematurity alters hypoxic and hypercapnic ventilatory responses in developing lambs

被引:37
作者
Davey, MG
Moss, TJ
McCrabb, GJ
Harding, R
机构
[1] Fetal and Neonatal Research Unit, Department of Physiology, Monash University, Melbourne
来源
RESPIRATION PHYSIOLOGY | 1996年 / 105卷 / 1-2期
关键词
control of breathing; development; preterm birth; hypoxic sensitivity; mammals; lamb; maturation;
D O I
10.1016/0034-5687(96)00038-2
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We have determined the effects of preterm birth on the postnatal development of ventilatory responses to progressive hypoxia and hypercapnia in awake lambs. Hypoxic and hypercapnic rebreathing tests were performed at weekly intervals in 5 preterm (born at 135 +/- 0.5 d) and 5 term (born at 146 +/- 0.2 d) lambs up to 6-7 weeks after birth. Term lambs were also studied at 25 weeks after birth. During rebreathing tests, we measured arterial P-O2 and P-CO2 and related them to minute ventilation (Vover dotI). Owing to variability in resting Pa-O2, hypoxic sensitivity was defined as the percentage increase in Vover dotI when Pa-O2 fell to 60% of resting values. Hypoxic sensitivities of preterm lambs did not change with age (68.9 +/- 24.4%), whereas values for term lambs more than doubled over the first 6 weeks (day 2, 73.9 +/- 15.8%; week 6, 227.4 +/- 24.9%) but returned to early postnatal values by week 25 (87.0 +/- 21.2%). Hypercapnic sensitivities (ml min(-1) kg(-1) mmHg CO2-1) of preterm lambs were lower than those of term lambs between day 2 and week 2, but reached values in term lambs thereafter. We conclude that preterm birth abolishes the normal postnatal maturation of hypoxic ventilatory sensitivity, and temporarily depresses hypercapnic sensitivity.
引用
收藏
页码:57 / 67
页数:11
相关论文
共 27 条
  • [1] BARTHELEMY L, 1989, RESPIRATION, V56, P63
  • [2] THE RESPONSE TO HYPOXIA OF ARTERIAL CHEMORECEPTORS IN FETAL SHEEP AND NEWBORN LAMBS
    BLANCO, CE
    DAWES, GS
    HANSON, MA
    MCCOOKE, HB
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1984, 351 (JUN): : 25 - 37
  • [3] BLANCO CE, 1987, CHEMORECEPTORS RESP, P216
  • [4] CHEMORECEPTOR REFLEXES IN NEW-BORN INFANT - EFFECTS OF VARYING DEGREES OF HYPOXIA ON HEART RATE AND VENTILATION IN A WARM ENVIRONMENT
    BRADY, JP
    CERUTI, E
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1966, 184 (03): : 631 - +
  • [5] VENTILATORY RESPONSE OF THE SLEEPING NEWBORN TO CO2 DURING NORMOXIC REBREATHING
    COHEN, G
    XU, C
    HENDERSONSMART, D
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1991, 71 (01) : 168 - 174
  • [6] CROSS KW, 1952, J PHYSIOL-LONDON, V117, P38
  • [7] VENTILATORY CONTROL AND CARBON-DIOXIDE RESPONSE IN PRETERM INFANTS WITH IDIOPATHIC APNEA
    DURAND, M
    CABAL, LA
    GONZALEZ, F
    GEORGIE, S
    BARBERIS, C
    HOPPENBROUWERS, T
    HODGMAN, JE
    [J]. AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1985, 139 (07): : 717 - 720
  • [8] BLUNTED VENTILATORY RESPONSE TO HYPOXIA IN CYANOTIC CONGENITAL HEART DISEASE
    EDELMAN, NH
    LAHIRI, S
    BRAUDO, L
    CHERNIAC.NS
    FISHMAN, AP
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1970, 282 (08) : 405 - &
  • [9] MATURATIONAL EFFECTS ON RESPIRATORY RESPONSES TO CARBON-DIOXIDE IN PREMATURE-INFANTS
    FRANTZ, ID
    ADLER, SM
    THACH, BT
    TAEUSCH, HW
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1976, 41 (01) : 41 - 45
  • [10] EFFECTS OF CAROTID-BODY MATURATION AND TERBUTALINE ON THE LARYNGEAL CHEMOREFLEX IN NEWBORN LAMBS
    GROGAARD, J
    KREUGER, E
    LINDSTROM, D
    SUNDELL, H
    [J]. PEDIATRIC RESEARCH, 1986, 20 (08) : 724 - 729