Estrogen treatment induces elevated expression of HMG1 in MCF-7 cells

被引:34
作者
Chau, KY
Lam, HYP
Lee, KLD [1 ]
机构
[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong
[2] Hong Kong Univ Sci & Technol, Kowloon, Hong Kong
关键词
D O I
10.1006/excr.1998.4052
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The high mobility group (HMG)1 protein is a highly conserved and ubiquitous chromosomal protein found enriched in active chromatin, In this study, we have investigated the effect of estrogen on the expression of the human high mobility group protein HMG1 gene and found that the HMG1 mRNA level in MCF-7 cells was sharply increased 2.5-fold after 30 min of estrogen treatment. Under continuous estrogen treatment, the HMG1 mRNA level decreased to a 1.5 times that of the basal level at 90 min and remained at this elevated level under estrogen treatment for up to 24 h. These results support the recent finding by Verrier et al, (C. S. Verrier, 1997, Mel. Endocrinol, 11, 1009-1019) that HMG1 promotes the binding of the estrogen receptor to the estrogen response element and further reinforce our believe that HMG1 plays a significant role in estrogen-induced gene expression. (C) 1998 Academic Press.
引用
收藏
页码:269 / 272
页数:4
相关论文
共 25 条
[1]  
CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[2]   HUMAN PROGESTERONE-RECEPTOR BINDING TO MOUSE MAMMARY-TUMOR VIRUS DEOXYRIBONUCLEIC-ACID - DEPENDENCE ON HORMONE AND NONRECEPTOR NUCLEAR FACTOR(S) [J].
EDWARDS, DP ;
KUHNEL, B ;
ESTES, PA ;
NORDEEN, SK .
MOLECULAR ENDOCRINOLOGY, 1989, 3 (02) :381-391
[3]   INTERACTION OF 2 NONHISTONE PROTEINS WITH THE ESTRADIOL RESPONSE ELEMENT OF THE AVIAN VITELLOGENIN GENE MODULATES THE BINDING OF ESTRADIOL-RECEPTOR COMPLEX [J].
FEAVERS, IM ;
JIRICNY, J ;
MONCHARMONT, B ;
SALUZ, HP ;
JOST, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7453-7457
[4]   Nuclear receptor coactivators [J].
Glass, CK ;
Rose, DW ;
Rosenfeld, MG .
CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (02) :222-232
[5]   DIFFERENTIAL STIMULATION OF HISTONE AND HIGH MOBILITY GROUP CHROMATIN PROTEIN-SYNTHESIS IN THE RAT UTERUS BY ESTROGEN [J].
GUO, JZ ;
GORSKI, J .
MOLECULAR ENDOCRINOLOGY, 1988, 2 (08) :686-692
[6]   NUCLEOLAR TRANSCRIPTION FACTOR HUBF CONTAINS A DNA-BINDING MOTIF WITH HOMOLOGY TO HMG PROTEINS [J].
JANTZEN, HM ;
ADMON, A ;
BELL, SP ;
TJIAN, R .
NATURE, 1990, 344 (6269) :830-836
[7]  
KATO Y, 1984, ENDOCRINOL JAPON, V31, P509
[8]   Nuclear hormone receptors: Ligand-activated regulators of transcription and diverse cell responses [J].
Katzenellenbogen, JA ;
Katzenellenbogen, BS .
CHEMISTRY & BIOLOGY, 1996, 3 (07) :529-536
[9]   THE ESTROGEN-RECEPTOR BINDS TIGHTLY TO ITS RESPONSIVE ELEMENT AS A LIGAND-INDUCED HOMODIMER [J].
KUMAR, V ;
CHAMBON, P .
CELL, 1988, 55 (01) :145-156
[10]  
LAM HYP, 1987, CANCER TREAT REP, V71, P901