Holmium:YAG lithotripsy:: Photothermal mechanism converts uric acid calculi to cyanide

被引：33

作者：

Teichman, JMH

Vassar, GJ

Glickman, RD

Beserra, CM

Cina, SJ

Thompson, IM

机构：

[1] Univ Texas, Hlth Sci Ctr, Div Urol, San Antonio, TX 78284 USA

[2] Univ Texas, Hlth Sci Ctr, Brooke Army Med Ctr, Dept Ophthalmol, San Antonio, TX USA

[3] Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX 78236 USA

[4] Off Epidemiol & Toxicol, Brooks AFB, TX USA

来源：

JOURNAL OF UROLOGY | 1998年 / 160卷 / 02期

关键词：

holmium; lithotripsy; laser; uric acid; calculi;

D O I：

10.1016/S0022-5347(01)62883-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: Holmium:YAG lithotripsy fragments stones through a photothermal mechanism. Uric acid when heated is known to be converted into cyanide, We test the hypothesis that holmium: YAG lithotripsy of uric acid calculi produces cyanide. Materials and Methods: Human calculi of known uric acid composition were irradiated with holmium:YAG energy in water. Stones received a total holmium:YAG energy of 0 (control), 0.1, 0.25, 0.5, 0.75, 1.0 or 1.25 kJ. The water in which lithotripsy was performed was analyzed for cyanide concentration. A graph was constructed to relate holmium:YAG energy to cyanide production. Results: Holmium:YAG lithotripsy of uric acid calculi in vitro produced cyanide consistently. Cyanide production correlated with total holmium:YAG energy (p <0.001). Conclusions: Holmium:YAG lithotripsy of uric acid calculi risks production of cyanide. This study raises significant safety issues.

引用

页码：320 / 324

页数：5

共 24 条

[1]

Ballantyne B., 1987, CLIN EXP TOXICOL CYA, P41

[2] SURVIVAL WITHOUT SEQUELAE FOLLOWING EXPOSURE TO 500 MG/M3 OF HYDROGEN-CYANIDE [J].