10-oximeguanacone, the first nitrogenated acetogenin derivative found to be a potent inhibitor of mitochondrial complex I

被引：29

作者：

Gallardo, T

Saez, J

Granados, H

Tormo, JR

Velez, ID

Brun, N

Torres, B

Cortes, D ^{[1
]}

机构：

[1] Univ Valencia, Fac Farm, Dept Farmacol Farmacognosia & Farmacodinamia, Burjassot 46100, Valencia, Spain

[2] Univ Antioquia, Dept Quim, Medellin AA1226, Colombia

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 08期

关键词：

D O I：

10.1021/np980079+

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new 10-keto bis-tetrahydrofuran acetogenin, guanacone (1), has been isolated from a cytotoxic extract of Annona aff. spraguei seeds. The 10-oximeguanacone derivative if is the first bioactive nitrogenated acetogenin found to be a very potent inhibitor of complex I. In addition, a SAR study of guanacone analogues is reported based on the titration of the NADH oxidase and NADH:ubiquinone oxidoreductase activities.

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页码：1001 / 1005

页数：5

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