Biological Phenotypes of Heart Failure With Preserved Ejection Fraction

被引：180

作者：

Lewis, Gavin A. ^{[1
,2
]}

Schelbert, Erik B. ^{[3
,4
,5
]}

Williams, Simon G. ^{[2
]}

Cunnington, Colin ^{[1
,6
]}

Ahmed, Fozia ^{[1
,6
]}

McDonagh, Theresa A. ^{[7
]}

Miller, Christopher A. ^{[1
,2
,8
]}

机构：

[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Cardiovasc Sci,Sch Med Sci, Oxford Rd, Manchester M13 9PL, Lancs, England

[2] Univ Hosp South Manchester NHS Fdn Trust, Manchester, Lancs, England

[3] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA

[4] UPMC Cardiovasc Magnet Resonance Ctr, Heart & Vasc Inst, Pittsburgh, PA USA

[5] Univ Pittsburgh, Clin & Translat Sci Inst, Pittsburgh, PA USA

[6] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Heart Ctr, Manchester Acad Hlth Sci Ctr, Oxford Rd, Manchester, Lancs, England

[7] Kings Coll Hosp London, London, England

[8] Univ Manchester, Wellcome Ctr Cell Matrix Res, Div Cell Matrix Biol & Regenerat Med, Sch Biol,Fac Biol Med & Hlth,Manchester Acad Hlth, Oxford Rd, Manchester, Lancs, England

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2017年 / 70卷 / 17期

关键词：

diastolic dysfunction; ejection fraction; heart failure; heart failure with preserved ejection fraction; myocardial fibrosis; titin; ABNORMAL CALCIUM HOMEOSTASIS; LEFT-VENTRICULAR HYPERTROPHY; NEPRILYSIN INHIBITOR LCZ696; ARTERIAL WAVE REFLECTIONS; AIR-FLOW OBSTRUCTION; DIASTOLIC DYSFUNCTION; MYOCARDIAL FIBROSIS; PULMONARY-HYPERTENSION; EXERCISE CAPACITY; OLDER PATIENTS;

D O I：

10.1016/j.jacc.2017.09.006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and which have potentially confounded previous HFpEF trials. A greater understanding of the in vivo human processes involved, and in particular, which are the causes and which are the downstream effects, may allow the syndrome of HFpEF to be distilled into distinct diagnoses based on the underlying biology. From this, specific interventions can follow, targeting individuals identified on the basis of their biological phenotype. This review describes the biological phenotypes of HFpEF and therapeutic interventions aimed at targeting these phenotypes. (C) 2017 by the American College of Cardiology Foundation.

引用

收藏

页码：2186 / 2200

页数：15

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