Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist

被引：154

作者：

Fujimoto, Y ^{[1
]}

Sasaki, T ^{[1
]}

Tsuchida, A ^{[1
]}

Chayama, K ^{[1
]}

机构：

[1] Hiroshima Univ, Sch Med, Dept Internal Med 1, Minami Ku, Hiroshima 7348551, Japan

来源：

FEBS LETTERS | 2001年 / 495卷 / 03期

关键词：

angiotensin II; pancreatic cancer; angiotensin II type 1 receptor; angiotensin II type 1 receptor antagonist;

D O I：

10.1016/S0014-5793(01)02377-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the expression of angiotensin II type 1 receptor (AT1) in pancreatic cancer, Both AT1 mRNA and protein were expressed in human pancreatic cancer tissues and cell lines. Binding assays showed that pancreatic dancer cells have specific binding sites for angiotensin II and that binding could be eliminated by treatment with a selective AT1 antagonist in a dose-dependent fashion. Surprisingly, the growth of cancer cells was significantly suppressed by treatment with antagonist, also in a dose-dependent manner. These observations suggest AT1 plays an important role in pancreatic cancer growth. Furthermore, ligand-induced inhibition of AT1 may be a useful therapeutic strategy. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：197 / 200

页数：4

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