Regulation of ion channel/neurotransmitter receptor function by RNA editing

被引：156

作者：

Seeburg, PH ^{[1
]}

Hartner, J ^{[1
]}

机构：

[1] Max Planck Inst Med Res, Dept Mol Neurobiol, D-69120 Heidelberg, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(03)00062-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RNA editing by select adenosine deamination (A-to-I editing) alters functional determinants in certain ion channels and neurotransmitter receptors in vertebrates and invertebrates. In most cases, edited and unedited versions of a given receptor/ channel co-exist to expand the functional space of the receptor population. Recent studies have characterized K+ channels in squid that are edited at multiple positions, revealed a role for Q/R site editing in AMPA receptor assembly, and demonstrated a link between serotonin levels and the extent of editing of a mammalian serotonin receptor.

引用

页码：279 / 283

页数：5

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