Electrical activity in endocrine pituitary cells in situ: A support for a multiple-function coding

被引：23

作者：

Bonnefont, X ^{[1
]}

Mollard, P ^{[1
]}

机构：

[1] CNRS, INSERM, Ctr Pharmacol Endocrinol, U469, F-34094 Montpellier 5, France

来源：

FEBS LETTERS | 2003年 / 548卷 / 1-3期

关键词：

timing information; action potential; calcium signaling; exocytosis; gene expression; growth;

D O I：

10.1016/S0014-5793(03)00727-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anterior pituitary is an endocrine gland that controls basic body functions. Pituitary cell functioning depends on membrane excitability, which induces cytosolic calcium rises. Here, we reported the first identification of small-amplitude voltage fluctuations that controlled spike firing in endocrine cells recorded in situ. Three patterns of voltage fluctuations were distinguishable by their durations (1-100 s). These patterns could be ordered on top of each other, namely in response to secretagogues. Thus, pituitary endocrine cells express in situ a cell code in which small-amplitude voltage fluctuations lead to a multimodal arrangement of spike firing, which may finely tune calcium-dependent functions. (C) 2003 Published by Else-tier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：49 / 52

页数：4

共 29 条

[1] Circadian rhythms in isolated brain regions [J].

Abe, M ;

Herzog, ED ;

Yamazaki, S ;

Straume, M ;

Tei, H ;

Sakaki, Y ;

Menaker, M ;

Block, GD .

JOURNAL OF NEUROSCIENCE, 2002, 22 (01) :350-356

[2] ACTION-POTENTIALS AND MEMBRANE ION CHANNELS IN CLONAL ANTERIOR-PITUITARY CELLS [J].

ADLER, M ;

WONG, BS ;

SABOL, SL ;

BUSIS, N ;

JACKSON, MB ;

WEIGHT, FF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (07) :2086-2090

[3] Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei [J].

Albus, H ;

Bonnefont, X ;

Chaves, I ;

Yasui, A ;

Doczy, J ;

van der Horst, GTJ ;

Meijer, JH .

CURRENT BIOLOGY, 2002, 12 (13) :1130-1133

[4] The versatility and universality of calcium signalling [J].

Berridge, MJ ;

Lipp, P ;

Bootman, MD .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (01) :11-21

[5] Rhythmic bursts of calcium transients in acute anterior pituitary slices [J].

Bonnefont, X ;

Fiekers, J ;

Creff, A ;

Mollard, P .

ENDOCRINOLOGY, 2000, 141 (03) :868-875

[6]

CORCUFF JB, 1993, J BIOL CHEM, V268, P22313

[7] Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus [J].

Cowley, MA ;

Smart, JL ;

Rubinstein, M ;

Cordán, MG ;

Diano, S ;

Horvath, TL ;

Cone, RD ;

Low, MJ .

NATURE, 2001, 411 (6836) :480-484

[8] The guinea-pig is not a rodent [J].

DErchia, AM ;

Gissi, C ;

Pesole, G ;

Saccone, C ;

Arnason, U .

NATURE, 1996, 381 (6583) :597-600

[9] DUAL MODULATION OF K-CHANNELS BY THYROTROPIN-RELEASING-HORMONE IN CLONAL PITUITARY-CELLS [J].

DUBINSKY, JM ;

OXFORD, GS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (12) :4282-4286

[10] INTRACELLULAR CA-2+-DEPENDENT PROTEIN-KINASE-C ACTIVATION MIMICS DELAYED-EFFECTS OF THYROTROPIN-RELEASING-HORMONE ON CLONAL PITUITARY CELL EXCITABILITY [J].

DUFY, B ;

JAKEN, S ;

BARKER, JL .

ENDOCRINOLOGY, 1987, 121 (02) :793-802

← 1 2 3 →