Critical maturational period of new neurons in adult dentate gyrus for their involvement in memory formation

被引：36

作者：

Aasebo, Ida E. J.

Blankvoort, Stefan

Tashiro, Ayumu ^{[1
]}

机构：

[1] Norwegian Univ Sci & Technol, Kavli Inst Syst Neurosci, N-7030 Trondheim, Norway

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2011年 / 33卷 / 06期

基金：

欧洲研究理事会;

关键词：

critical period; hippocampus; immediate-early genes; memory; neurogenesis; GENERATED GRANULE CELLS; BORN HIPPOCAMPAL-NEURONS; ENHANCED SYNAPTIC PLASTICITY; LONG-TERM-MEMORY; SPATIAL MEMORY; DOUBLE DISSOCIATION; PATTERN SEPARATION; BASAL DENDRITES; NEWBORN NEURONS; C-FOS;

D O I：

10.1111/j.1460-9568.2011.07608.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult dentate gyrus produces new neurons continuously throughout life. Multiple lines of evidence have pointed to the possibility that young neurons during a certain maturational stage mediate an important role in memory processing. In this review, we highlight the existing evidence of a 'critical period' for new neurons in their involvement in memory formation, describe the unique properties of young neurons as potential mechanisms underlying the critical period, and discuss the implications of the critical period for the function of adult neurogenesis.

引用

收藏

页码：1094 / 1100

页数：7

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